{"id":3318,"date":"2026-03-11T10:05:58","date_gmt":"2026-03-11T01:05:58","guid":{"rendered":"https:\/\/handai-seizo.jp\/?page_id=3318"},"modified":"2026-04-15T11:23:26","modified_gmt":"2026-04-15T02:23:26","slug":"2026-2","status":"publish","type":"page","link":"https:\/\/handai-seizo.jp\/?page_id=3318","title":{"rendered":"\u767a\u8868\u8ad6\u65872026"},"content":{"rendered":"\n

4) \u91cd\u6c34\u7d20\u5275\u85ac\u3092\u62e1\u5145\u3059\u308b\u91cd\u30a2\u30eb\u30ad\u30eb\u5316\u5264<\/a><\/strong>
\u6fa4\u9593 \u5584\u6210\u3001\u962a \u4e00\u7a42
\u548c\u5149\u7d14\u85ac\u6642\u5831<\/em>, Vol.94, No.2, 2026\u5e74<\/strong>4\u6708<\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

3) \u91cd\u533b\u85ac\u54c1\u958b\u767a\u3092\u6307\u5411\u3057\u305f\u4f4d\u7f6e\u9078\u629e\u7684\u91cd\u6c34\u7d20\u5316\u6cd5<\/strong>
\u6fa4\u9593 \u5584\u6210
\u6709\u6a5f\u5408\u6210\u5316\u5b66\u5354\u4f1a\u8a8c, <\/em>2026\u5e74<\/strong>1\u6708\u53f7, p.50-61<\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

2) Controlled formation of versatile methylated compounds based on ring opening of 4-methyl-1-siloxy-1,4-epoxy-1,4-dihydrobenzene<\/a><\/strong>
Takaaki Aijima,\u2021<\/sup> Jin Tokunaga,\u2021<\/sup> Sota Yoshimura, Yuki Itabashi, Tsunayoshi Takehara, Takeyuki Suzuki, Shuji Akai, Yoshinari Sawama
(\u2021<\/sup>equally contributed)
RSC Adv<\/em>. 2026<\/strong>, 16<\/em>, 15586\u201315590.
DOI: 10.1039\/D6RA01853J<\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

Abstract:<\/strong> We report an FeCl3<\/sub>-catalyzed transformation of 4-methyl-1-siloxy-1,4-epoxy-1,4-dihydrobenzene. Reaction in toluene gave the phenol product, whereas the addition of i<\/em>-PrOH in 1,2-dichloroethane induced desilylative ring opening to produce 4-hydroxy-4-methyl-2,4-cyclohexadienone, which subsequently underwent a CO2<\/sub>Me-induced regioselective 1,2-methyl shift (C4 to C3) to afford 6-methyl-2,4-cyclohexadienone. This product bears a methyl-substituted quaternary carbon center that is difficult to access by existing methods and serves as a versatile intermediate for further structural elaboration. These results highlight a new mode of skeletal rearrangement and demonstrate regioselective control over competing reaction pathways.<\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

1) Synthetic Studies Toward Rubioncolin B<\/a><\/strong>
Takaaki Aijima, Shuji Akai, Yoshinari Sawama
Eur. J. Org. Chem.<\/em> 2026<\/strong>, 29<\/em>, e202501103.
DOI: 10.1002\/ejoc.202501103<\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

Abstract:<\/strong> Herein, we report our synthetic studies toward rubioncolin B (1<\/strong>), a heptacyclic naphthohydroquinone dimer with antitumor activity. Our strategy is based on the intermolecular [4\u2009+\u20092]-cycloaddition reaction between an ortho<\/em>-naphthoquinone methide (o<\/em>-NQM), which is generated in situ from a 1-naphthol derivative under catalytic Lewis acid conditions, and a naphthofuran derivative, thereby enabling the construction of a hexacyclic compound. We then explored three synthetic approaches for appending the remaining ring structure to the hexacyclic compound. Among them, the sequence involving the introduction of a Wittig reagent and subsequent cyclization proved effective, furnishing a cyclic acetal with the same ring structure as 1<\/strong>. This strategy not only demonstrates that accessing the highly congested architecture of 1<\/strong> is feasible but also provides a versatile platform for the synthesis of structurally diverse analogs, thereby facilitating subsequent biological investigations, including structure\u2013activity relationship studies.<\/p>\n","protected":false},"excerpt":{"rendered":"

4) \u91cd\u6c34\u7d20\u5275\u85ac\u3092\u62e1\u5145\u3059\u308b\u91cd\u30a2\u30eb\u30ad\u30eb\u5316\u5264\u6fa4\u9593 \u5584\u6210\u3001\u962a \u4e00\u7a42\u548c\u5149\u7d14\u85ac\u6642\u5831, Vol.94, No.2, 2026\u5e744\u6708 3) \u91cd\u533b\u85ac\u54c1\u958b\u767a\u3092\u6307\u5411\u3057\u305f\u4f4d\u7f6e\u9078\u629e\u7684\u91cd\u6c34\u7d20\u5316\u6cd5\u6fa4\u9593 \u5584\u6210\u6709\u6a5f\u5408\u6210\u5316\u5b66\u5354\u4f1a\u8a8c, 2026\u5e741\u6708\u53f7, […]<\/p>\n","protected":false},"author":2,"featured_media":3437,"parent":125,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_locale":"ja","_original_post":"https:\/\/handai-seizo.jp\/?page_id=3318","footnotes":""},"class_list":["post-3318","page","type-page","status-publish","has-post-thumbnail","hentry","ja"],"_links":{"self":[{"href":"https:\/\/handai-seizo.jp\/index.php?rest_route=\/wp\/v2\/pages\/3318","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/handai-seizo.jp\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/handai-seizo.jp\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/handai-seizo.jp\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/handai-seizo.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=3318"}],"version-history":[{"count":8,"href":"https:\/\/handai-seizo.jp\/index.php?rest_route=\/wp\/v2\/pages\/3318\/revisions"}],"predecessor-version":[{"id":3528,"href":"https:\/\/handai-seizo.jp\/index.php?rest_route=\/wp\/v2\/pages\/3318\/revisions\/3528"}],"up":[{"embeddable":true,"href":"https:\/\/handai-seizo.jp\/index.php?rest_route=\/wp\/v2\/pages\/125"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/handai-seizo.jp\/index.php?rest_route=\/wp\/v2\/media\/3437"}],"wp:attachment":[{"href":"https:\/\/handai-seizo.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=3318"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}